Date of Award
2016
Document Type
Thesis
Degree Name
Bachelors
Department
Natural Sciences
First Advisor
Beulig, Alfred
Area of Concentration
Chemistry
Abstract
Gulf War Illness (GWI) is a debilitating condition affecting roughly 250,000 veterans of the 1991 Gulf War (GW). Patients with GWI experience cognitive decline, immune activation, physical discomfort and pain, along with limited mobility and decreased overall quality of life. Previous studies conducted at the Roskamp Institute and elsewhere have implicated mitochondrial dysfunction, altered lipid metabolism and peroxisomal dysfunction as the biological features of GWI most likely caused by exposure to cholinergic pesticides and nerve agents in the GW theater. This study aims to use innovative, mass spectrometry based-lipidomic analysis to identify the involvement of these factors in the pathology of GWI. The ultimate goal of this study is to utilize this information to identify potential biochemical targets for the development of therapeutic measures in mouse models, which could allow subsequent translation of these therapies for alleviating the symptoms of ill GW veterans.
Recommended Citation
Seroka, Austin, "LIPIDOMIC IDENTIFICATION OF THERAPEUTIC TARGETS IN A MOUSE MODEL OF GULF WAR ILLNESS" (2016). Theses & ETDs. 5277.
https://digitalcommons.ncf.edu/theses_etds/5277