Date of Award

2025

Document Type

Thesis

Degree Name

Bachelors

Department

Natural Sciences

First Advisor

Clore, Amy

Area of Concentration

Biopsychology, Neuroscience

Abstract

Alopecia areata (AA) is an autoimmune disorder in which hair is lost abruptly because the immune system damages hair follicles. In this thesis, I will first review the epidemiology and biology of the disorder and will then discuss the therapeutic potential of JAK-STAT pathway inhibition for AA and the pharmacodynamics and pharmacokinetics of JAK inhibitors, in particular Ruxolitinib. The Janus kinase/signal transducer/activator of transcription JAK-STAT pathway is a major driver of immune and inflammatory response, and its dysregulation contributes to AA. Ruxolitinib, by preventing JAK’s activity, reduces pro-inflammatory cytokines, allowing restoration of immune privilege in hair follicles and regenerating hair. The pharmacokinetics of Ruxolitinib, including its absorption, distribution, metabolism, and excretion, is reviewed herein. In addition, this thesis focuses on the biopsychological nature of AA, including the impact of stress and hormone dysregulation on the course of the disease. The role of androgens, thyroid hormones, and the HPA axis in AA are discussed, and the importance of an integrated approach to treatment. Combining drugs with psychological interventions and lifestyle changes can boost treatment efficacy. It is an integrated approach that works to address the complexities of AA and aims to provide patients with higher quality of life through specific therapy and intervention

Download

Share

COinS