Date of Award

2024

Document Type

Thesis

Degree Name

Bachelors

Department

Social Sciences

First Advisor

Cook, Peter

Area of Concentration

Biopsychology, Neuroscience

Abstract

Traumatic brain injuries (TBIs) are a significant health issue, and there are a wide variety of efforts taking place to research the neural mechanisms involved in an attempt to find treatments. Importantly, there is a deficit in literature regarding the choroid plexus in how it relates to traumatic brain injuries. Furthermore, more research must be done to compare cellular mechanisms between ventricles effectively. There is no recorded study history of the third ventricle choroid plexus following TBI. Within this thesis, I investigated the differences in the third ventricle’s choroid plexus immunohistological presentation within healthy mice versus the brains of TBI mice to establish characteristics in morphological structure and cellular behavior. This was done through qualitative analysis of the immunohistological presentation of 10 adult male mice. The stains that were analyzed included hematoxylin and eosin (H&E), glial fibrillary acidic protein (GFAP), and Iba1 (Ionized calcium-binding adaptor molecule 1). In conclusion, there were no notable differences between the groups of mice, as there were no visible injury effects within the choroid plexus of mice that experienced closed-head mild TBI.

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