Date of Award
2024
Document Type
Thesis
Degree Name
Bachelors
Department
Natural Sciences
First Advisor
Gilchrist, Sandra
Area of Concentration
Biology
Abstract
Type 2 Diabetes Mellitus (T2DM) and Alzheimer’s Disease (AD) are becoming more widespread as the aging population expands. Researchers have recently investigated the physiological links between T2DM and AD due to their co-occurrence. Insulin resistance plays a pivotal role in both, impacting cognitive function. Additionally, oxidative stress increases over time in both T2DM and AD, potentially impacting their progression. The accumulation of amyloid-β and tau is a central hypothesis in understanding AD, with T2DM suggesting a possible connection to amyloid-β accumulation. This paper explores the key connection between T2DM and AD, with a focus on insulin resistance, oxidative stress, and the accumulation of amyloid-β and tau.
Recommended Citation
Cardenas, Nayelis, "Biological Connections Between Type 2 Diabetes Mellitus and Alzheimer's Disease:
A Review of Insulin Resistance, Oxidative Stress, and Accumulation of Amyloid-β and
Tau" (2024). Theses & ETDs. 6534.
https://digitalcommons.ncf.edu/theses_etds/6534