Author

Alia Quadir

Date of Award

2021

Document Type

Thesis

Degree Name

Bachelors

Department

Natural Sciences

First Advisor

Casto, Kathleen

Area of Concentration

Neuroscience

Abstract

Addiction is a pervasive public health problem, with around 20.4 million Americans struggling with some kind of addiction. Currently, our understanding of addiction is dominated by the “Brain Disease Model of Addiction” (BDMA), which posits that addiction is a chronic, relapsing brain disease resulting from the dysfunctional neurobiological changes in the brain caused by chronic drug use. I review the evidence for drug-induced neurobiological changes in the brain and provide a critique of the BDMA. I evaluate the usefulness BDMA from the perspective of the ongoing Opioid Crisis and sketch the outline of an alternative model of addiction, a trauma-informed, transdisciplinary biopsychosocial-ecological model, which better accommodates the root causes of the Opioid Crisis and addiction in general. Finally, I review potential treatment and policy consequences of this new model and future directions for addiction research.

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