Date of Award
2018
Document Type
Thesis
Degree Name
Bachelors
Department
Natural Sciences
First Advisor
Scudder, Paul
Area of Concentration
Chemistry
Abstract
Bacterial infections are a leading cause of death in many countries worldwide. Antibiotic resistance is becoming more and more prevalent, leading to outbreaks of resistant bacteria. Additionally, there have been few successful attempts at making new antibiotics in the past three decades. This thesis is an attempt to create a 1,2,3-triazole analogue of linezolid: an oxazolidinone antibiotic. The goal of creating this antibiotic is to increase gramnegative activity of this antibiotic as compared to linezolid, and to create an antibiotic that bacteria are not yet resistant to, as resistances to oxazolidinones have already been discovered. Three model click reactions were attempted. One of these worked very well, and the target compound was successfully synthesized using that procedure. The compound was found to be pure, and in a good yield. The compound has not been tested for antibiotic activity.
Recommended Citation
Calzadilla, Jessica, "Partial Synthesis of a Novel Oxazolidinone Analogue" (2018). Theses & ETDs. 5490.
https://digitalcommons.ncf.edu/theses_etds/5490