Date of Award

2016

Document Type

Thesis

Degree Name

Bachelors

Department

Natural Sciences

First Advisor

Gilchrist, Sandra

Keywords

Anticoagulants, Dogs, Warfarin, Blood

Area of Concentration

Biology

Abstract

Anticoagulants, such as Warfarin, are prescribed if a dog is at risk of forming a blood clot or to prevent one from growing larger. Warfarin will chemically inhibit the viability of vitamin K and interfere with the synthesis of coagulating protein factors in the liver and other chemicals that are necessary for clot formation. In essence, Warfarin increases how long it take to make fibrin by delaying the release of fibrinogen. This thesis aims to determine whether a five percent Warfarin solution is significant in slowing the time it takes canine blood to clot. This was done by extracting samples of blood from fifteen canines under clinical conditions and recording the amount of time in seconds it took those samples to clot. For each canine, eight trials were conducted simultaneously. Overall, it was determined that there was a significant difference between the means of the time taken to clot for all fifteen dogs combined and for dogs aged one to six.

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