Date of Award
2012
Document Type
Thesis
Degree Name
Bachelors
Department
Natural Sciences
First Advisor
Beulig, Alfred
Keywords
COPD, Murine, Lung, Real time PCR, th17, YST Cells
Area of Concentration
Biology
Abstract
Chronic obstructive pulmonary disease (COPD) affects roughly 80 million people worldwide and accounts for 5-10% of global deaths (Chen, Pociask and McAleer 2011). In 2001 close to three million people died due to complications resulting from the disease (Lopez, Mathers and Ezzati 2006). Furthermore, WHO estimates rank COPD as the 4th leading cause of death in the world (Mathers and Loncar 2006). The prevalence and growing threat to global health caused by COPD has translated into abundant research targeted at understanding the underlying mechanisms that govern the disease process. The surge in research has shown an interesting correlation between elevated T helper cell 17 (Th17) cytokine levels, specifically IL-17 and associated signaling, and disease severity. In the current study, Real Time PCR was used to analyze the gene products of IL-17 signaling (IL-23, CCL2, CCL20, CXCL1, CXCL5, and MMP9) in murine mode of COPD.
Recommended Citation
Mangels, Christopher E., "A Transcript Analysis of Il-17 Signaling Related Genes in Response to Respiratory Syncytial Virus Infection in Experimental Elastase/Lps Injured Murine Lungs" (2012). Theses & ETDs. 4639.
https://digitalcommons.ncf.edu/theses_etds/4639