Date of Award

2012

Document Type

Thesis

Degree Name

Bachelors

Department

Natural Sciences

First Advisor

Beulig, Alfred

Keywords

COPD, Murine, Lung, Real time PCR, th17, YST Cells

Area of Concentration

Biology

Abstract

Chronic obstructive pulmonary disease (COPD) affects roughly 80 million people worldwide and accounts for 5-10% of global deaths (Chen, Pociask and McAleer 2011). In 2001 close to three million people died due to complications resulting from the disease (Lopez, Mathers and Ezzati 2006). Furthermore, WHO estimates rank COPD as the 4th leading cause of death in the world (Mathers and Loncar 2006). The prevalence and growing threat to global health caused by COPD has translated into abundant research targeted at understanding the underlying mechanisms that govern the disease process. The surge in research has shown an interesting correlation between elevated T helper cell 17 (Th17) cytokine levels, specifically IL-17 and associated signaling, and disease severity. In the current study, Real Time PCR was used to analyze the gene products of IL-17 signaling (IL-23, CCL2, CCL20, CXCL1, CXCL5, and MMP9) in murine mode of COPD.

Rights

This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.

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