Date of Award

2012

Document Type

Thesis

Degree Name

Bachelors

Department

Natural Sciences

First Advisor

Walstrom, Katherine

Keywords

Metabolism, Hepatocytes, Glycol Ethers

Area of Concentration

Chemistry

Abstract

The National Toxicology Program reports more than 80,000 chemicals registered for use in the United States. An estimated 2,000 new chemicals are introduced for use in everyday items such as foods, personal care products, prescription drugs, household cleaners, and lawn care products each year. The glycol ethers ethylene glycol monohexyl ether and ethylene glycol 2-ethylhexyl ether lack toxicity and metabolism studies even though their chemical structures are similar to ethylene glycol monobutyl ether, a hematotoxin. Cryopreserved hepatocytes from female and male human, mouse, and rats were used to determine the half-lives of glycol ethers as well as possible metabolites. The half-life of ethylene glycol 2-ethylhexyl ether was shorter than the half-life of ethylene glycol monohexyl ether. However, the half-life of ethylene glycol monobutyl ether could not be determined possibly due to metabolite interference and detection of the compound in the negative control. Also, glucuronidation was observed with ethylene glycol 2-ethylhexyl ether which is the first time a metabolite has been detected for this glycol ether in the literature.

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